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http://hdl.handle.net/2282/672
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| Tittel: | Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas |
| Forfattere: | Skjelbred, Camilla Furu
Sæbø, Mona
Hjartåker, Anette
Grotmol, Tom
Hansteen, Inger-Lise
Tveit, Kjell M.
Hoff, Geir
Kure, Elin H. |
| Dato: | 19-Dec-2007 |
| Forlagets versjon: | http://dx.doi.org/10.1186/1471-2407-7-228 |
| Sammendrag: | BACKGROUND: The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle
factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables
are associated with an increased risk of CRC. The dietary effects may be modulated by genetic
polymorphisms in biotransformation genes. In this study we aimed to evaluate the role of dietary
factors in combination with genetic factors in the different stages of colorectal carcinogenesis in a
Norwegian population.
METHODS: We used a case-control study design (234 carcinomas, 229 high-risk adenomas, 762
low-risk adenomas and 400 controls) to test the association between dietary factors (meat versus
fruit, berries and vegetables) genetic polymorphisms in biotransformation genes (GSTM1, GSTT1,
GSTP1 Ile105Val, EPHX1 Tyr113His and EPHX1 His139Arg), and risk of colorectal carcinomas and
adenomas. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by binary logistic
regression.
RESULTS: A higher ratio of total meat to total fruit, berry and vegetable intake was positively
associated with both high and low-risk adenomas, with approximately twice the higher risk in the
2nd quartile compared to the lowest quartile. For the high-risk adenomas this positive association
was more obvious for the common allele (Tyr allele) of the EPHX1 codon 113 polymorphism. An
association was also observed for the EPHX1 codon 113 polymorphism in the low-risk adenomas,
although not as obvious.
CONCLUSION: Although, the majority of the comparison groups are not significant, our results
suggest an increased risk of colorectal adenomas in individuals for some of the higher ratios of total
meat to total fruit, berry and vegetable intake. In addition the study supports the notion that the
biotransformation enzymes GSTM1, GSTP1 and EPHX1 may modify the effect of dietary factors on
the risk of developing colorectal carcinoma and adenoma. |
| Nøkkelord: | Colorectal cancer
Risk factors
Meat
Vegetables
Carcinomas
Adenomas
Genetics
Polymorphisms |
| Forlag: | BioMed Central |
| Dokumenttype: | Journal article |
| URI: | http://hdl.handle.net/2282/672 |
| Vises i samlingene: | Medisinsk genetikk
Onkologi
Institutt for natur-, helse- og miljøvernfag
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