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|Title: ||Modeling Pseudomonas aeruginosa biofilm detachment|
|Authors: ||Kommedal, Roald|
|Issue Date: ||2003 |
|Abstract: ||The mechanisms and modeling of surface biofilm detachment are evaluated in this study using data from
Pseudomonas aeruginosa experiments and a standard one dimensional mass balance biofilm modeling approach.
The aim of this study is to identify an appropriate expression to model the net surface Pseudomonas aeruginosa
biofilm detachment. Measured values of biofilm thickness, biomass concentration, low rate shear stress and
substrate concentrations were used to calibrate detachment models. Most literature models were able to stabilize
the simulated biofilm after parameter estimation, however, few showed good quality of fit. Multi-parameter
models proposed here gave good quality of fit, but estimated uncertainties of the parameter values were high.
Detachment rate expressions which included biofilm biomass failed parameter estimation. Based on sensitivity
analysis, model complexity and residual least square error (quality of fit), it was concluded that both a growth
relation, a lumped parameter describing biofilm size and imposed shear stress, should be included in the overall
surface detachment Pseudomonas aeruginosa model.|
|Publisher: ||Høgskolen i Telemark|
|Document type: ||Working paper|
|Appears in Collections:||HiT notat|
Institutt for prosess-, energi- og miljøteknologi
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